to make a great effort;

abnegation; ache; agony; disease; feeling of pain; illness; pain; physical suffering; sick; sickness; to ache;

disease; pain; sickness; diseases; sick; illness; infirmity; abnegation; ache; infirmities; bruise; sufferings; to ache; pains; agony; and pain; sorrow; physical suffering; grief; travail; feeling of pain; affliction;